The most popular open-source AI scientist, AI co-scientist, and researcher projects on GitHub — across all domains, with live stars and forks.
The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery 🧑🔬
The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search
AutoGPT is the vision of accessible AI for everyone, to use and to build on. Our mission is to provide the tools, so that you can focus on what matters.
AI agents running research on single-GPU nanochat training automatically
🙌 OpenHands: AI-Driven Development
🌟 The Multi-Agent Framework: First AI Software Company, Towards Natural Language Programming
A natural language interface for computers
A programming framework for agentic AI
Universal memory layer for AI Agents
Framework for orchestrating role-playing, autonomous AI agents. By fostering collaborative intelligence, CrewAI empowers agents to work together seamlessly, tackling complex tasks.
LlamaIndex is the leading document agent and OCR platform
aider is AI pair programming in your terminal
Build, run, and manage agent platforms.
DSPy: The framework for programming—not prompting—language models
Build resilient agents.
A modular graph-based Retrieval-Augmented Generation (RAG) system
ChatDev 2.0: Dev All through LLM-powered Multi-Agent Collaboration
An LLM-powered knowledge curation system that researches a topic and generates a full-length report with citations.
Turn any AI agent into an AI Scientist. The #1 Agent Skills library for science, used by 160,000+ scientists worldwide. 140 ready-to-use skills plus 100+ scientific databases covering biology, chemistry, medicine, and drug discovery. Compatible with Cursor, Claude Code, Codex, Antigravity, and the open Agent Skills standard.
An autonomous agent that conducts deep research on any data using any LLM providers
JARVIS, a system to connect LLMs with ML community. Paper: https://arxiv.org/pdf/2303.17580.pdf
SWE-agent takes a GitHub issue and tries to automatically fix it, using your LM of choice. It can also be employed for offensive cybersecurity or competitive coding challenges. [NeurIPS 2024]
Evals is a framework for evaluating LLMs and LLM systems, and an open-source registry of benchmarks.
🐫 CAMEL: The first and the best multi-agent framework. Finding the Scaling Law of Agents. https://www.camel-ai.org
Open source code for AlphaFold 2.
Open-source reproduction of OpenAI-style deep research using LangGraph and multi-step planning.
Fully local web research and report writing assistant
[NeurIPS2025] "AI-Researcher: Autonomous Scientific Innovation" -- A production-ready version: https://novix.science/chat
SWE-bench: Can Language Models Resolve Real-world Github Issues?
Paper2Code: Automating Code Generation from Scientific Papers in Machine Learning
AllenAI's post-training codebase
Biomni: a general-purpose biomedical AI agent
📄 🤖 AI for medical and scientific papers
A curated list of awesome AI tools, libraries, papers, datasets, and frameworks that accelerate scientific discovery — from physics and chemistry to biology, materials, and beyond.
AI agent specialized in single-cell type annotation and analysis for genomics research.
Biomni-AD: AI Co-Scientist for Biomedical Research (AD datalake integration, Open Source)
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