Pathway
Gamma-secretase (Notch pathway)
Gamma-secretase is the enzyme complex that activates Notch signaling by cleaving the Notch receptor. Inhibiting it suppresses Notch-driven proliferation, which has shown striking activity in desmoid tumors.
1
Drugs
1
Trials tracked
1
Resolved
1
Indications
Drugs hitting this target
Trials targeting γ-secretase
1 benchmarkIndications
About γ-secretase
What is γ-secretase?
Gamma-secretase is the enzyme complex that activates Notch signaling by cleaving the Notch receptor. Inhibiting it suppresses Notch-driven proliferation, which has shown striking activity in desmoid tumors.
Which drugs target γ-secretase?
Therapies acting on γ-secretase tracked here include Varegacestat.