GeneGene: TYK2
Tyrosine kinase 2 (TYK2)
TYK2 is a JAK-family kinase that transmits signaling from type-I interferon and select interleukins (IL-12, IL-23). Selective TYK2 inhibition dampens these inflammatory pathways while sparing the broader JAK1/2/3 signaling, an approach pursued across autoimmune diseases such as dermatomyositis and lupus.
1
Drugs
2
Trials tracked
1
Resolved
2
Indications
Drugs hitting this target
Trials targeting TYK2
2 benchmarksIndications
About TYK2
What is TYK2?
TYK2 is a JAK-family kinase that transmits signaling from type-I interferon and select interleukins (IL-12, IL-23). Selective TYK2 inhibition dampens these inflammatory pathways while sparing the broader JAK1/2/3 signaling, an approach pursued across autoimmune diseases such as dermatomyositis and lupus.
Which drugs target TYK2?
Therapies acting on TYK2 tracked here include GLPG3667.