GeneGene: GNRHR

GnRH receptor (GNRHR)

The gonadotropin-releasing hormone receptor governs the release of LH and FSH. Sustained GnRH-agonist stimulation paradoxically desensitizes the receptor and suppresses sex-hormone production, the basis for halting central precocious puberty.

Forecast a trial in the ArenaAll targets & genes
1
Drugs
1
Trials tracked
1
Resolved
1
Indications

Drugs hitting this target

FP-001 (leuprolide mesylate)· Long-acting GnRH-agonist depot

Trials targeting GnRH-R

1 benchmark
ResolvedPhase 3

Casppian Phase 3: FP-001 leuprolide mesylate 42 mg q6mo Central Precocious Puberty (CPP)

FP-001 (leuprolide mesylate) · Central precocious puberty

Dec 24, 2025Clinical Trials

Indications

Central precocious puberty· CPP

About GnRH-R

What is GnRH-R?

The gonadotropin-releasing hormone receptor governs the release of LH and FSH. Sustained GnRH-agonist stimulation paradoxically desensitizes the receptor and suppresses sex-hormone production, the basis for halting central precocious puberty.

Which drugs target GnRH-R?

Therapies acting on GnRH-R tracked here include FP-001 (leuprolide mesylate).

References

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