Oral nonpeptide GLP-1 receptor agonistEli Lilly

Orforglipron

Orforglipron is an oral, nonpeptide GLP-1 receptor agonist from Eli Lilly. As a once-daily pill it could broaden access to incretin-based weight loss beyond injectables, including weight maintenance after switching from semaglutide or tirzepatide.

Forecast a trial in the Arena Browse all benchmarks

Trials tracked

Resolved

Indications

Targets

Orforglipron forecasting benchmarks

1 benchmark

ResolvedPhase 3

ATTAIN-MAINTAIN (orforglipron) weight maintenance after switching from Wegovy or Zepbound

Orforglipron · Obesity

Dec 18, 2025Clinical Trials

Mechanism & molecular targets

GLP-1R· gene

Indications studied

Obesity

Developed by

Eli Lilly· LLY

About Orforglipron

What is Orforglipron?

What does Orforglipron target?

Orforglipron acts on GLP-1 receptor (GLP1R).

How well do AI models predict Orforglipron trial outcomes?

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